Information about Hosting Offer
Hosting Offer: Intercollegiate Faculty of Biotechnology University of Gdansk and Medical University of Gdansk
Information
| Role | Hosting Offer |
|---|---|
| Organisation | Intercollegiate Faculty of Biotechnology University of Gdansk and Medical University of Gdansk |
| Organisation type | Public |
| City | Gdańsk |
| HR Excellence in Research Award from the European Commission | yes |
| National evaluation category | A+ (excellent) |
| Faculty / Dept. / Division / Laboratory / Research group | Structural Biology Laboratory |
| Website | https://en.biotech.ug.edu.pl/about_ifb/about_ifb |
| Thematic area/field | NZ – Life Sciences / NZ1 Molecular biology, structural biology, biotechnology |
| Key words | Macromolecular Machines; DNA replication; DNA repair; mitochondria |
| Short summary of activities and expertise | IFB is a leading research and teaching institution that since 2002 has the status of the European Centre of Excellence in Biosafety and Molecular Biomedicine (since EU FP5) and is ranked highly by the Ministry of Science and Higher Education (MNiSW) regarding scientific effectiveness. In 2017, in a parametric assessment, IFB was granted the highest-level category, A+. In 2020, the Polish Accreditation Committee (PKA) awarded the Biotechnology study programme at IFB the Certificate of Educational Excellence in the category “Excellent programme - excellence in education”. These are the only distinctions of that kind granted in Poland in the area of biological sciences. Detailed information about IFB can be found at: https://biotech.ug.edu.pl/sites/default/files/_nodes/strona-biotechnologia/50161/files/raport_2018-2020_stronami.pdf |
| Role and profile of key persons (incl. supervisor) | The applicant will be hosted by the Structural Biology Laboratory headed by Prof. Michal Roman Szymanski. The Szymanski lab aims to understand the basic principles underlying the assembly of multi-protein macromolecular machines involved in nucleic acid metabolism, characterize their structure and function to gain insight into their mechanism of action. More information about the lab can be found at: https://mrslab.ug.edu.pl/ |
| Previous and current involvement in research and training programmes | Dr. Szymanski was the POLONEZ 2 Fellow (2017-2019). Currently, the research in the Szymanski lab is supported by: ERC Starting Grant (2020 – 2025, 1.5 million €) FNP First Team 3 Grant (2018 – 2023; 855k €) and EMBO Installation Grant (2019 – 2023; 150k €) |
| Relevant publications and/or research/innovation products | 1. Reyes-Aldrete, E., Dill, E.A., Bussetta, C., Szymanski, M.R., Diemer, G., Maindola, P., White M.A., Bujalowski, W.M., Choi, K.H., Morais, M.C. Biochemical and Biophysical Characterization of the dsDNA packaging motor from the Lactococcus lactis bacteriophage asccphi28. Viruses. 2020. (doi: 10.1101/2020.11.17.383745). 2. Jain, N., Blauch, L.R., Szymanski M.R., Das, R., Tang, S.K.Y., Yin, W.Y., Fire, A.Z. Transcription polymerase-catalyzed emergence of novel RNA replicons. Science. 2020 Apr 10;368(6487). pii: eaay0688. doi: 10.1126/science.aay0688. Epub 2020 Mar 26. 3. Dosekova P., Dubiel ,A., Karlowicz, A., Zietkiewicz, S., Rydzanicz, M., Habalova V., Pienkowski V.M., Skirkova, M., Han V., Mosejova, A., Gdovinova, Z., Kaliszewska, M., Tońska, K., Szymanski, M.R., Skorvanek, M., Ploski, R. Whole exome sequencing identifies a homozygous POLG2 missense variant in an adult patient presenting with optic atrophy, movement disorders, premature ovarian failure and mitochondrial DNA depletion. Eur J Med Genet. 2019 Nov 26:103821. doi: 10.1016/j.ejmg.2019.103821. [Epub ahead of print] 4. Szymanski, M.R., Yu, A., Gmyrek, A.M., White, M.A., Molineux, I.J., Lee, J.C., Yin W.Y. A novel domain in human EXOG converts apoptotic endonuclease to DNA- repair exonuclease. Nature Communications. 2017 May 3;8:14959. 5. Sohl, C.D*., Szymanski, M.R*., Mislak, A.C., Shumate, K.C., Amiralaei, S., Schinazi, F.R., Anderson K.S., Yin W.Y. Probing the Structural and Molecular Basis of Nucleotide Selectivity by Human Mitochondrial DNA Polymerase γ. PNAS. 2015 Jul 14;112(28):8596-601. *equal contribution 6. Szymanski, M.R., Kuznetsov, V.B., Shumate, C., Meng, Q., Lee, Y-S., Patel, G., Patel, S.S., Yin W.Y. Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase. EMBO J. 2015 Jul 14; 34(14):1959-70. |
| Key research facilities, infrastructure, and equipment | https://mrslab.ug.edu.pl/resources/ |
| Hosting arrangements | https://mrslab.ug.edu.pl/resources/ |
| Key research facilities, infrastructure, and equipment | Open access to infrastructure in the Faculty https://biotech.ug.edu.pl/wspolpraca/aparatura_equipment |
| Intersectoral secondments options | |
| Other benefits | Support from English-speaking personnel, support from peers, and academic mentoring. |
| Candidate sought | Documented experience in at least one of the following: Structural Biology, Molecular Biology, Biochemistry. Excellent written and oral communication skills in English. Show a good level of independence, self-motivation and reliability. |
| Have you hosted POLONEZ Fellows or MSCA IF Fellows before? | no |
| Candidatures deadline | 2021-11-14 |
Contact | |
| First name | Michal |
| Last name | Szymanski |
| michal.szymanski@biotech.ug.edu.pl | |
| Phone number | |
