Information about Hosting Offer
Hosting Offer: International Institute of Molecular and Cell Biology in Warsaw
Information
| Role | Hosting Offer |
|---|---|
| Organisation | International Institute of Molecular and Cell Biology in Warsaw |
| Organisation type | Public |
| City | Warsaw |
| HR Excellence in Research Award from the European Commission | yes |
| National evaluation category | A+ (excellent) |
| Faculty / Dept. / Division / Laboratory / Research group | Laboratory of Iron Homeostasis |
| Website | https://www.iimcb.gov.pl/en/research/laboratories/9-laboratory-of-iron-homeostasis#tab1 |
| Thematic area/field | NZ – Life Sciences / NZ4 Biology of tissues, organs and organisms |
| Key words | Iron homeostasis, hepatocytes, iron-recycling macrophages, liver endothelial cells |
| Short summary of activities and expertise | The International Institute of Molecular and Cell Biology in Warsaw (IIMCB) is one of the top-ranked (A+), modern and recognized Polish research institutes, conducting studies in the broad fields of molecular, cellular and structural biology. Its mission is to support ambitious scientists of any nationality, driven by passion to pursue frontier research. Based on organizational standards of top-level research centres, and follows the principles of scientific freedom, integrity and responsibility, IIMCB providing its scientists with the best working conditions to grow. More about IIMCB please find at: https://www.iimcb.gov.pl/en/institute/annual-reports/21-annual-report-2020 The applicant will be hosted by the LABORATORY OF IRON HOMEOSTASIS, headed by Dr KATARZYNA MLECZKO-SANECKA. Her group aims to better understand cell-type-specific iron regulatory processes, both from the perspective of the control of iron levels and in the context of iron-related signaling functions that regulate cell physiology. |
| Role and profile of key persons (incl. supervisor) | The supervisor, Dr KATARZYNA MLECZKO-SANECKA carried out her doctoral and post-doctoral research in the laboratory jointly led by Martina Muckenthaler and Matthias Hentze, affiliated at the European Molecular Biology Laboratory (EMBL) and the University of Heidelberg. The main objective of her work was to gain new insights into the genetic control of iron homeostasis. In 2017, she established her laboratory at the International Institute of Molecular and Cell Biology (IIMCB) – the Laboratory of Iron Homeostasis. Her group combines mechanistic cell-based studies (involving loss-of-function CRISPR knock-outs) with work on mouse models (using advanced flow cytometry, FACS and ‘omics’ approaches) to identify how regulation of cellular and systemic iron levels is achieved and how it cross talks to specialized cell functions in the body. The current interests of the lab focus on the mechanism of ‘iron sensing’ within the liver tissue microenvironment, the control of iron deposition in hepatocytes, and on the mechanisms of iron-recycling in macrophages. |
| Previous and current involvement in research and training programmes | Dr Katarzyna Mleczko-Sanecka was the POLONEZ Fellow. She carried out the POLONEZ grant entitled: Deciphering BMP6 regulatory mechanisms using CRISPR/Cas9-based screening approach (2017-2018), Based on her own experience she will provide guidance and supervision for the post-doc fellow. She is currently conducting two research projects funded by NCN: 1) OPUS entitled 'Deciphering novel mechanisms that control iron sensing and iron accumulation in the liver' and 2) SONATA BIS entitled 'Identifying unique adaptive responses of red pulp macrophages to iron deficiency'. |
| Relevant publications and/or research/innovation products | Major publications: 1 ) Mleczko-Sanecka K, Silvestri L. (2021) Cell-type-specific insights into iron regulatory processes; 96(1):110-127; https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajh.26001 2 ) Mleczko-Sanecka K., da Silva A.R., Call D., Neves J., Schmeer N., Damm G., Seehofer D., Muckenthaler M.U., (2017). Imatinib and spironolactone suppress hepcidin expression, Haematologica;102(7):1173-84; http://www.haematologica.org/content/102/7/1173 3 ) Mleczko-Sanecka K., Roche F., da Silva A.R., Call D., D’Alessio F., Ragab A., Lapinski P.E., Ummanni R., Korf U., Oakes C., Damm G., D’Alessandro L.A., Klingmüller U., King P.D., Boutros M., Hentze M.W., Muckenthaler M.U., (2014). Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling, Blood, 123(10):1574-85 (Article with a Comment: Arosio P. New signaling pathways for hepcidin regulation. Blood, 2014; 123(10):1433-4). |
| Key research facilities, infrastructure, and equipment | The majority of IIMCB equipment is concentrated in the Core Facilities and Zebrafish Core Facility, with unlimited access for our researchers. There are over 50 pieces of equipment that are grouped into several units based on leading technologies and applications: 1)Bioimaging and High-Throughput Screening, 2) Biomolecular Analytics, 3) Genomics, 4) Structural Biology and 5) Cell Biology. The list of equipment can be found at https://www.iimcb.gov.pl/en/equipment-facilities/equipment/ In addition, IIMCB is located in a large biomedical campus (Ochota Campus, the largest complex of biomedical academic entities in this part of Europe) that offers access to equipment and various possibilities of training and collaboration. |
| Hosting arrangements | The majority of IIMCB equipment is concentrated in the Core Facilities and Zebrafish Core Facility, with unlimited access for our researchers. There are over 50 pieces of equipment that are grouped into several units based on leading technologies and applications: 1)Bioimaging and High-Throughput Screening, 2) Biomolecular Analytics, 3) Genomics, 4) Structural Biology and 5) Cell Biology. The list of equipment can be found at https://www.iimcb.gov.pl/en/equipment-facilities/equipment/ In addition, IIMCB is located in a large biomedical campus (Ochota Campus, the largest complex of biomedical academic entities in this part of Europe) that offers access to equipment and various possibilities of training and collaboration. |
| Key research facilities, infrastructure, and equipment | Dr. Mleczko-Sanecka will act as a mentor and fully support the applicant in his/her research and career progress. The fellow will receive necessary hands-on training and theoretical knowledge on various methods, including mouse/primary cell handling, flow cytometry, FACS sorting from the experienced researchers in the Mleczko-Sanecka lab. His or her planned project will be tightly integrated with the research of the Mleczko-Sanecka group. The fellow will also be a part of IIMCB’s research community. He or she will participate in weekly open seminars (a forum to share experiences and network with in-house researchers and outstanding invited scientists) and will benefit from networking events that are organized at IIMCB and neighboring institutes of the Ochota Campus. If needed, the fellow will be offered a free participation in required certification courses on the usage of laboratory animals and professional in-house trainings on the use of equipment. On daily basis the researcher will be supported by professional English-speaking administrative personnel and will receive assistance from the HR Unit in organizing his or her stay in Poland. The IIMCB’s Grants Office, experienced in managing international grants, will ensure the researcher smooth integration with the funding system and efficient implementation of the project. Institute has successfully hosted 4 Fellows within Polonez 1 (NCN) and 2 Fellows within MSCA-ITN (FP7 and H2020). Altogether, the supportive environment at IIMCB will the fellow to devote his/her time primarily to scientific tasks and career development. |
| Intersectoral secondments options | The intersectoral secondment will be discussed between the fellow and the supervisor and adjusted to the interests and career goals of the candidate. |
| Other benefits | Company Social Benefits Fund, Private health care, Multisport card, Full technical, administrative and organizational support from professional English-speaking personnel, Participation in courses, scientific training, support from peers, and academic mentoring. |
| Candidate sought | The ideal candidate should have: - strong interests in molecular aspects of physiology and passion for science; - solid background in cell-or-animal based research; - written and spoken fluency in English; - the ability to conceive research steps and work independently, and think analytically; - very good interpersonal skills and a collaborative attitude. |
| Have you hosted POLONEZ Fellows or MSCA IF Fellows before? | no |
| Candidatures deadline | 2021-10-31 |
Contact | |
| First name | Justyna |
| Last name | Mitan |
| jmitan@iimcb.gov.pl | |
| Phone number | |
