Information about Hosting Offer
Hosting Offer: Biotechnology Centre, Silesian University of Technology
Information
| Role | Hosting Offer |
|---|---|
| Organisation | Biotechnology Centre, Silesian University of Technology |
| Organisation type | Public |
| City | Gliwice |
| HR Excellence in Research Award from the European Commission | yes |
| National evaluation category | A+ (excellent) |
| Faculty / Dept. / Division / Laboratory / Research group | Tunneling Group |
| Website | www.tunnelinggroup.pl |
| Thematic area/field | ST – Physical Sciences and Engineering / ST4 Chemistry |
| Key words | molecular modelling, protein structure, drug design, antimicrobial peptides, enzyme engineering, rare diseases, protein evolution |
| Short summary of activities and expertise | The main activity of the group borders the fields of molecular biology and computational chemistry. We are using an advanced theoretical approach to investigate the properties of various enzymes, to design biologically active compounds, and to help experimentalists interpret their results. |
| Role and profile of key persons (incl. supervisor) | Artur Góra PhD, since 2014 head of the independent scientific laboratory – Tunneling Group located in Biotechnology Centre in Politechnika Slaska (BCSUT). In 2016-2019 Deputy Director of Sciences of BCSUT. The one of the initiator of the core facility for the protein-ligand interaction study at SUT. Research interests: computational chemistry, bioinformatics and tool development. He has developed a new method for protein interior analysis using molecular probe tracking approach. His expertise lies in the engineering of enzymes activity and selectivity, proteins structure study, analysis of molecular aspects of rare diseases, development of drugs and inhibitors using combination of experimental and computational methods. Management & participation in 9 national & international projects, 3 years’-experience in institute management, responsible for coordination and development strategy of institute combining multidisciplinary research (chemistry, structural biology, molecular biology, microbiology, bioinformatics, medical and environmental biotechnology). |
| Previous and current involvement in research and training programmes | We have experience in NCN project management (OPUS, SONATA-BIS, HARMONIA), NCBiR. Potential supervisor has experience in MSCA type of grants. National Centre of Polish Science (NCN) – Role of the gates and anchoring residues in enzymes activity and selectivity - SONATA-BIS - finalized National Centre of Polish Science (NCN) – Reversible modification of enzyme activity and substrate specificity by engineering of the ligand exchange pathways - HARMONIA - finalized National Centre for Research and Development (NCBiR) – Antimicrobials of the Sea: Identification of Marine-derived Bacteriocins and Their Antimicrobial Activity – bilateral grant with TUBITAK Marmara Research Center - running, OPUS - Design of high selective and safe juvenile hormone epoxide hydrolases inhibitors targeting selected pests based on the combination of analysis of intramolecular voids dynamics and enzymes evolution study (NCN) running, Horizon Europa - Teaching Lytic Polysaccharide Monooxygenases to do Cytochrome P450 Catalysis - starting June 2022. |
| Relevant publications and/or research/innovation products | 1. Bzówka M.; Mitusińska K.; Hopko K.; Góra A.; Computational insights into the known inhibitors of human soluble epoxide hydrolase. Drug Discovery Today 2021, doi: 10.1016/j.drudis.2021.05.017 2. Fischer A.; Sellner M.; Mitusińska K.; Bzówka M.; Lill M. A.; Góra A.; Smieško M.; Computational Selectivity Assessment of Protease Inhibitors against SARS-CoV-2 Int. J. Mol. Sci. 2021, 22(4), 2065 doi: 10.3390/ ijms22042065. 3. Bzówka M., Mitusińska K., Raczyńska A., Samol A., Tuszynski J.A., Góra A., Structural and Evolutionary Analysis Indicate That the SARS-CoV-2 Mpro Is a Challenging Target for Small-Molecule Inhibitor Design, Int. J. Mol. Sci. 2020, 21(7), 3099 doi: 10.3390/ijms21093099. 4. Mitusińska K., Raczyńska A., Bzówka M., Bagrowska W., Góra A. Applications of water molecules for analysis of macromolecule properties. Computational and Structural Biotechnology Journal 2020, 18, 355-365, doi:10.1016/j.csbj.2020.02.001 5. Magdziarz, T.; Mitusińska, K.; Bzówka, M.; Raczyńska, A.; Stańczak, A.; Banas, M.; Bagrowska, W.; Góra, A. AQUA-DUCT 1.0: structural and functional analysis of macromolecules from an intramolecular voids perspective. Bioinformatics 2020, 36(8), 2599-2601, doi:10.1093/bioinformatics/btz946 |
| Key research facilities, infrastructure, and equipment | The existing infrastructure of the Biotechnology Centre ensures general availability of state-of-the-art scientific equipment including: a supercomputing centre; RT-PCR; UHPLC; UV-VIS, FT-IR, FT Raman, MS, and NMR spectrophotometers; light, fluorescent, and confocal microscopes; atomic force microscopy (AFM); nucleic acids and protein structure/function analysis equipment. |
| Hosting arrangements | The existing infrastructure of the Biotechnology Centre ensures general availability of state-of-the-art scientific equipment including: a supercomputing centre; RT-PCR; UHPLC; UV-VIS, FT-IR, FT Raman, MS, and NMR spectrophotometers; light, fluorescent, and confocal microscopes; atomic force microscopy (AFM); nucleic acids and protein structure/function analysis equipment. |
| Key research facilities, infrastructure, and equipment | Silesian University of Technology offers full administrative and accounting support for projects carried out by its employees. Relevant project management experience is demonstrated by current and past projects and organization of scientific events which have been carried out. The Project Management Center (CZP) tasks include: (i) monitoring and control of the project implementation and project budgets, (ii) overseeing the project financing, (iii) management training and knowledge transfer for project leaders. Applicant will receive intensive training run by CZP, which will contribute to the proper implementation of proposed research tasks. Project Management Center co-operates with other organizational units of the Silesian University of Technology assisting with preparation and implementation of projects. The support is ensured on every stage of project, from daily activities up to emergent case and implementation of alternative activities, by dedicated specialists from the Office for European Projects and the Office for Financial Service of Projects. Financial and accounting services of all projects at the Silesian University of Technology are provided by Kwestura of the Silesian University of Technology . |
| Intersectoral secondments options | |
| Other benefits | Large list of co-operation institutions including National Institute of Oncology, Polish Academy of Sciences, University Alberta in Canada, Wageningen University in Netherlands, Masaryk University in Czech Republic and many others |
| Candidate sought | We are searching for strong candidates with experience in computational chemistry, biotechnology but also in experimental biochemistry, protein engineering etc. |
| Have you hosted POLONEZ Fellows or MSCA IF Fellows before? | no |
| Candidatures deadline | 2022-04-15 |
Contact | |
| First name | Artur |
| Last name | Góra |
| artur.gora@polsl.pl | |
| Phone number | |
